The Mythus game introduced the Accursed, "enemies of humanity", and, in fact, the unpublished game Unhallowed was going to deal with this in much greater depth.

Why bother with such a group? Is not an arch-enemy formidable enough? Yes, sort of. There reaches a point, however, when said arch-enemy's escapes stop being believable. This becomes a double problem if the HPs travel from dimension to dimension, hopping from genre to genre. But if the villains are tied together through a loose network, they can be defeated, and yet more is happening, and newer, worse villains can be brought forth believably. Or, the villains can become the thread linking the various genres, as players hop from HardWired to Chaos Changeling to Mythus, and so on and so forth.

Does a group as evil as this have a place in a Cyberpunk setting? Of course it does, that should be plain. However, the Accursed generally operate via magic and evil beings. In Cyberpunk, such stuff is usually the domain of mythology and legends. (The reader is referred to the section on cross-genre play for an alternate approach.)

In HardWired, the Accursed take on behind-the-scenes roles. They finance certain corporate activities, and perhaps some research labs; if one wants a truly illuminated game, they could be a grand conspiracy, secretly pulling the strings of world governments and corporations.

Some potential roles for the Accursed:

• The Accursed are the Secret Masters, controlling the massive corporations and corrupt governments from behind the scenes. They are using this world as a stepping stone, a staging area from which they drain the resources before bringing them to bear. Further, since the Accursed span multiple parallel worlds, certain of their number have strong, mythical allies (Fiends and such), and can bring such forces to bear on a party which has taken a heroic turn. (GURPS CthulhuPunk and GURPS Voodoo would be particularly helpful in planning and playing such a scenario.)
• The Accursed may be merely beginning to invade this timestream, using this parallel world as a test of humanity's self-destruction. They may be operating to drive humanity further into the downward spiral, encouraging corruption and despair. Perhaps they intend to drive the world into a mad holocaust, with feeble governments bowing to the whims of fanatics, wiping each other from the face of the planet with nuclear devices.
• Perhaps the Accursed are making the first strides into space, and are based on the less technologically-advanced parallels, and so are using front companies to finance space vehicles which will later be transported back to Ærth or others, to wipe their continual enemies out once and for all!

Having such a bunch of villains can add continuity to the campaign, and can do something rare in the true Cyberpunk tradition: give the HPs a reason to believe that they can make a difference!